In vanilla Terraria, many Hardmode bosses require other bosses to be defeated before they can be fought, creating a linear sequence of progression. The Calamity Mod makes heavy adjustments to the progression of Hardmode, removing many restrictions on the order in which bosses must be fought, and also (if the Early Hardmode Progression Rework configuration option is enabled) changing the obtainment method of early-Hardmode ores and Hallowed Bars. The Starter Bag contains numerous useful items and can be opened to help speed up the beginning of the game. In every new player's inventory, there will be a Starter Bag. See the Revengeance Mode or Death Mode pages for changes that occur exclusively within those modes.

The changes listed here occur as long as the Calamity Mod is installed, and are not restricted to any modded difficulty modes. The Calamity Mod also changes multiple vanilla item recipes.

The Calamity Mod changes several aspects and details regarding vanilla Terraria content, ranging from the order in which bosses can be fought in to which items are sold by NPCs.

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